GENERAL INFORMATION
Established:  1993
Ownership:  Private

Core business

Bio-Imaging Systems in the field of transluminescence in
molecular biology. Early detection of cancer.

Employees:  9
Turnover (KUS$):  2,300
Market regions:  France, Germany, Japan, USA

Overview

DNR - Imaging Systems ltd. (former known as Dinco & Rhenium Ind.
Ltd) is a private company, established in 1993, involved in the
development, production, marketing and sales of multi-purpose
imaging systems for biological applications.

DNR is developing a line of improved bio-imaging products, which
is based on the successful concepts of the previous line of
Bio-Imaging systems.
In the diagnostic arena, the DNR has started developing its F-WOS
system (Fluorescent Working Station). This system will provide
for the first time an industrial solution for using Fluorescent
labeling of biological samples in the diagnostic world. The need
for such a system is a direct result of some recent
break-throughs in the field, such as the near completion of the
Human-Genome project, and the rapid development of new
Fluorescent diagnostic techniques.

DNR has designed and developed, 3 types of Bio-Imaging systems
over the last 7 years. Each system was designed to fit a specific
market sector: Hi-End, Mid-Range, and Low-End. The systems are
able to handle fluorescent, Chemi -luminance and Visible dyes.
The top end system has full automation capabilities.
DNR's Bio-Imaging products are designed to answer to the newest
needs of researchers in molecular biology and genetic research
field.

* The Bio-Imaging systems are characterized by an easy and
friendly Graphic User Interface on one hand, and high performance
on the other.
* The systems provide the researcher with a truly versatile
platform with a wide spectrum of capabilities.
* The systems give high performance at a lower price than most
competitive systems.
* DNR's systems are marketed by one of the leading companies in
this field in world - Amersham Bioscience (former - "Pharmacia
Biotech").

Bio-imaging devices are designed to enhance, image, and document
the different patterns of the labeled samples. An expert with the
assistant of software packages can then analyze these patterns,
at a later stage.
Different labeling methods are used for different tasks, and
require different Bio-Imaging devices to deal with them. In the
past, most conventional imaging methods have involved the use of
radio-nuclide or heavy metal ion labels. Emission from these
samples has been recorded as images on photographic film.
Radioactive markers are the most sensitive imaging method
available. However, this method has significant disadvantages: it
is labor intensive; it requires special laboratories, and it
needs special disposal measures.

Today new methods have become available. In one of them
fluorescent probes are used to label biological samples and
provide detectable signals. In another method, chemiluminscence,
chemical markers are used to label biological samples and provide
detectable signals. These new methods require new Imaging systems
to provide the desired imaging and documentation for the labeled
samples.

One of the new emerging techniques used today in the research of
molecular biology and genetics is fluorescent labeling. In this
technique fluorescent probes are used to mark a specific location
in a biological specimen. Using this technique one can quite
easily detect different genes, chromosomes, DNA strands,
proteins, and bacteria. The enormous effort, going these days,
into genetic research, together with the constant development of
new Fluorescent dyes contributes to the rapid advancement in this
area.